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Rating one of the best berberine dietary supplements of 2022

Berberine is an natural complement with a historical past that’s 1000’s of years lengthy.

It’s been used and researched to deal with every part from joint ache to weight reduction to controlling diabetes in folks with insulin insensitivity.

Berberine’s mechanism of motion is complicated, but it surely seems to change the best way your physique’s mitochondria generate vitality, which could point out why it’s useful for such all kinds of illnesses.

Should you’re searching for a high quality weight reduction complement sourced from an natural treatment, berberine is price a glance.

We’ve examined what’s obtainable in the marketplace proper now and give you the highest ten, ranked in accordance with efficacy.

Why You Ought to Belief Us

    Our advisory panel and our analysis workforce rank one of the best well being merchandise and dietary supplements based mostly on efficiency, label accuracy, and the efficacy of the substances within the merchandise.


Final up to date: September 22, 2022
Berberine dietary supplements thought of: 25
Hours of analysis: 45
Specialists reviewed: 10
Scientific papers referenced: 32


Finest General

1. Nuzena Berberine Pure +

  • Helps coronary heart well being, blood sugar management, and gastrointestinal perform
  • Every veggie capsule boasts 600 mg of extremely pure and extremely concentrated berberine
  • Its purity is independently verified by third-party lab testing
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Finest for intestine well being

thorne berberine

2. Thorne Analysis Berberine

  • Pure product with a minimal quantity of extraneous substances
  • Probably the greatest berberine dietary supplements on the market that is available in a vegetarian capsule
  • 500 mg per capsule
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Finest for girls

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3. aSquared Vitamin Berberine

  • Extremely pure berberine complement in a gelatin capsule
  • Offers a really strong 500 mg of berberine per capsule at a 60% focus
  • Has a wonderful repute for purity and high quality in its dietary supplements
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Finest for weight reduction

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4. Integrative Therapeutics Berberine Advanced

  • It makes use of three completely different plant species as sources of berberine
  • Mixed with a number of of the opposite associated compounds within the plant which are bioactive
  • Gluten-free
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5. We Like Nutritional vitamins Berberine

  • It has a simplistic design and allergen-free certification
  • The one different substances are gelatin and rice flour
  • Gluten-free, dairy-free, egg-free, and soy free
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6. Divine Bounty Berberine

  • 600 mg per capsule
  • Offers 20% extra berberine per serving than most of its different opponents
  • It is available in a vegetarian capsule
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7. Naturebell Berberine Plus

  • Offers a strong berberine complement with a excessive dose of 600 mg per capsule
  • Good purity and complement design
  • Wheat-free, soy-free, dairy-free, and egg-free
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8. Dr. Whitaker’s Scientific Grade Berberine

  • Branded and clinically grade
  • 500 mg of berberine per capsule
  • Gelatin capsule
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  • Has superior absorption properties
  • 500 mg of berberine per capsule
  • Brown rice focus filler within the vegetarian capsule
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  • 600 mg berberine complement
  • Vegetarian capsule
  • It’s licensed freed from many frequent allergens like gluten and soy
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1. Nuzena Berberine Pure +

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If you wish to leverage the advantages of berberine for higher coronary heart well being, blood sugar management, and gastrointestinal perform, look no additional than Nuzena Berberine Pure +. 

Every veggie capsule boasts 600 mg of extremely pure and extremely concentrated berberine, placing it on the high of our listing thanks each to its excessive dosage and to its excessive purity. On high of that, its purity is independently verified by third-party lab testing, and it’s licensed non-GMO, gluten-free, and vegan-friendly.

For all of those causes, Berberine Pure + by Nuzena is our primary decide for 2021.

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2. Thorne Analysis Berberine

thorne berberine

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Thorne Analysis is a widely known identify within the rarer, much less frequent natural extracts as a result of they virtually all the time make a high quality, pure product with a minimal quantity of extraneous substances.

That’s actually the case right here, as this is likely one of the greatest berberine dietary supplements on the market that is available in a vegetarian capsule. At 500 mg per capsule, it doesn’t skimp on the dosage both.

3. Integrative Therapeutics Berberine Advanced

integrative therapeutics berberine

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Not like many different corporations, Integrative Therapeutics is doing one thing revolutionary with its berberine complement. It makes use of three completely different plant species as sources of berberine, and one in every of them is mixed with a number of of the opposite associated compounds within the plant which are bioactive.

Because of this this berberine complement could possibly be extra prone to work if others have failed you, although if all you need is 100% pure berberine, there are higher choices in the marketplace.

4. NOW Dietary supplements Berberine Glucose Assist

now berberine glucose suppport

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NOW Dietary supplements makes a fairly strong berberine complement that’s particularly geared in direction of utilizing berberine for blood sugar management.

It accomplishes this by delivering its berberine content material in MCT oil, a wonderful ship platform for the lipid-soluble biologically lively compounds in berberine.

The one draw back? This methodology of supply places a restrict on the dosage; every capsule delivers solely 400 mg of berberine

5. We Like Nutritional vitamins Berberine

we like vitamins berberine

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The dosage of berberine on this complement (600 mg per capsule) is middle-of-the-road, however its simplistic design and its allergen-free certification make it a really strong alternative.

The one different substances are gelatin (for the capsule–sorry, vegetarians) and rice flour, and the truth that it’s gluten, dairy, egg, and soy free are all to its profit.

6. Divine Bounty Berberine

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For these searching for a excessive dosage berberine complement, Divine Bounty is an efficient alternative. With 600 mg per capsule, it gives 20% extra berberine per serving than most of its different opponents.

Add to that the truth that it is available in a vegetarian capsule and doesn’t have a lot in the best way of additional fillers and stabilizers, and also you’ve obtained a profitable components for many who want a better than traditional dose of berberine.

7. Naturebell Berberine Plus

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Naturebell gives a strong berberine complement with a excessive dose of 600 mg per capsule, which is good for extra aggressive supplementation routines capturing for 1200 mg per day in two separate doses. Except for this, the purity and complement design is nice however not the very best.

8. Dr. Whitaker’s Scientific Grade Berberine

whitaker berberine

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Although it’s branded as scientific grade, this berberine complement doesn’t look like of upper dosage or high quality than anything in the marketplace.

It has the standard 500 mg of berberine per capsule, and the capsules are made from gelatin together with a couple of further fillers and stabilizers not discovered within the opponents, making it arduous to justify rating this complement any larger.

9. Toniq Berberine

toniq berberine

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Toniq delivers a extremely purified model of berberine extract at a strong 500 mg dosage. It’s an incredible go-to possibility if you need a easy and pure berberine complement at a typical dosage, although the capsule has a couple of extra binders and fillers than we’d prefer to see.

10. Sunergetic Berberine

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Sunergentic has a high-dose 600 mg berberine complement that’s delivered in a vegetarian capsule.

It’s additionally licensed freed from many frequent allergens like gluten and soy, although the principle draw back of the berberine complement from this lesser-known complement producer is its reliance on silica as a filler for its capsules. Greater-quality manufacturers will go for one thing extra pure, like rice flour.

Class winners

Finest berberine total: Nuzena Berberine Pure +

With 600 mg of berberine per capsule, unbiased lab verification for purity, and no extraneous substances, Nuzena is a good alternative. Excessive dose, super-pure, and straightforward to make use of.

Finest berberine for intestine well being: Thorne Analysis Berberine

In case you are utilizing berberine for intestine issues, just like the bacterial overgrowth linked to SIBO, you desire a berberine complement that’s freed from any extraneous substances. That’s why we suggest Thorne Analysis Berberine for intestine well being—its ultra-simple complement design makes it well-suited for this software.

Finest berberine for weight reduction: Integrative Therapeutics Berberine

Integrative Therapeutics gives berberine alongside two different natural extracts for digestive and metabolic well being: goldenseal and Oregon grape extracts. These could possibly be helpful for stopping a few of the troublesome gastrointestinal uncomfortable side effects that may come together with beginning a weight reduction weight loss plan. 

Finest berberine for girls: NOW Dietary supplements Berberine Glucose Assist

Girls profit from the extremely bioavailable supply of berberine on this complement, with simpler absorption due to the MCT oil used to dissolve the lively compounds in berberine. The five hundred mg dosage is an efficient match for a lot of girls as effectively

Finest berberine for coronary heart well being: Thorne Analysis Berberine

Berberine has been utilized in a couple of scientific research to cut back blood lipids and blood strain, which may help lower your threat of coronary heart illness. To observe the protocols from these research as carefully as doable, go for a pure and concentrated berberine complement like Thorne Analysis Berberine, which boasts 500 mg of 85% berberine extract.

Finest berberine for blood sugar management: Nuzena Berberine Pure + 

One in all berberine’s hottest functions helps to manage blood sugar, and the high-dose formulation of Nuzena Berberine Pure + is completely suited to this use case: its 600 mg of concentrated berberine extract per capsule leads the trade in dosage. 

Who should purchase berberine?

Berberine seems to modulate the best way your physique processes and makes use of vitality. Which means berberine dietary supplements are tailor-made for a couple of particular use instances:

Individuals who wish to management their blood sugar extra successfully. Berberine has been studied most intently as a approach to assist deal with insulin insensitivity in individuals who have sort two diabetes or who’ve metabolic syndrome. Berberine may aid you enhance blood glucose regulation and struggle again towards metabolic dysfunction.

Individuals who wish to fight the adverse well being results of weight problems. By itself, berberine is just not a improbable weight reduction complement, but it surely does do a reasonably good job serving to to ameliorate the adverse well being results related to being chubby.

It would assist decrease your physique fats share, but it surely’s far stronger at enhancing well being points generally related to an unhealthy weight loss plan and extreme physique weight, resembling excessive ldl cholesterol and excessive blood lipids.

Some analysis means that berberine works for weight reduction, however not in addition to a few of the extra high-powered compounds for weight reduction like inexperienced tea extract

Individuals with irritable bowel syndrome. Curiously, berberine additionally has a devoted core of advocates amongst individuals who have irritable bowel syndrome.

Whereas the mechanism of motion right here is just not solely clear, scientific analysis does assist the usage of berberine to cut back a few of the signs of irritable bowel syndrome, so in case you have gastrointestinal issues attributable to IBS, you will have success utilizing berberine as effectively.

How we ranked

Berberine’s specialised makes use of knowledgeable our rating process: since there are a number of scientific trials on utilizing berberine, we have been capable of examine the supply mechanism, dosage, and purity of the merchandise we thought of to the gold commonplace of what’s utilized in scientific analysis. Particularly, we seemed for:

A deal with delivering berberine. As a result of berberine is particularly geared in direction of sure well being issues, and since a lot of the proof for it comes from scientific trials that used pure berberine extracts of their experiments, we required the berberine dietary supplements in our rankings to ship solely berberine as their lively ingredient.

Whereas it’s not essentially true that berberine should be taken to the exclusion of all different dietary supplements, that is how it’s often prescribed in scientific analysis. No merchandise that included non-berberine lively substances made it into our rankings.

Proof-based berberine dosage. Subsequent, after specializing in berberine-specific dietary supplements, we seemed on the dosage.

Because the analysis on berberine sometimes makes use of 900-1500 mg each day doses divided up into a number of smaller tablets, we required that the berberine dietary supplements in our rankings ship a dose that was simply parsed out into two or three tablets or capsules per day to achieve this clinically efficient dosage vary.

Something with lower than 400 or greater than 600 mg per capsule was dropped from consideration.

High quality substances and no pointless binders or fillers. Past simply the dosage, we additionally seemed on the purity of the berberine dietary supplements. Did they make the most of unbiased laboratory testing for purity, like Nuzena?

Did the capsules have a clear, easy ingredient design, or have been they bloated with silica and different binders or coloring brokers?

These have been the sorts of issues we thought of when evaluating the remaining berberine dietary supplements. Whereas a cellulose-based capsule versus a gelatin-based capsule was a pleasant perk (for strict vegetarians and vegans), it wasn’t a core analysis standards.

After pooling outcomes from all of those standards, we had our last rankings of one of the best berberine dietary supplements in the marketplace. 


Q: What does berberine do for the physique?

A: Berberine primarily acts in your physique’s metabolic atmosphere, serving to to forestall the stresses of a poor weight loss plan and the stresses of being chubby or overweight from inflicting will increase in your blood lipids and blood ldl cholesterol.

It additionally exerts a potent degree of management over poorly regulated blood sugar, which is characteristically seen in sort two diabetes and metabolic syndrome.

These mechanisms are pretty well-researched, however berberine additionally seems to exert some direct advantages on weight reduction, and should have advantages for controlling irritable bowel syndrome as effectively—the reasoning behind why it really works in these functions are much less well-understood.

Q: Can I take berberine and metformin on the identical time?

A: Berberine has been studied together with metformin in a single examine (1), and no adverse drug interactions have been reported.

Nonetheless, it’s dangerous to take a prescription medicine and a complement which are purported to do the identical factor (i.e. decrease blood sugar) on the identical time, since whether or not these medication work together, or inhibit every others’ mechanism of motion is unknown.

It is best to discuss to your physician first for those who take metformin (or every other prescription drug) and would additionally prefer to strive berberine alongside it to raised management your blood sugar.

Q: Can berberine have an effect on testosterone ranges?

A: Some primary organic analysis performed in cells on Petri dishes means that sure sorts of cells (largely tumor cells, or ovary cells) might scale back their expression of testosterone and different androgens, however when it comes to results in your physique total, there’s no proof that berberine will both decrease or increase your testosterone ranges.

Q: How lengthy must you take berberine?

A: Scientific analysis means that getting the advantages of berberine might take six to eight weeks to realize its results, and a number of other research have discovered advantages at twelve weeks as effectively.

Past the timeframe of some months, it’s not clear for those who ought to take berberine indefinitely, and any potential long-term well being results haven’t been explored intimately.

Q: Does berberine assist with weight reduction?

A: Some analysis means that berberine might assist with short-term weight reduction, which is nice provided that we already know berberine will be useful at controlling well being points related to being chubby or overweight.

Whereas it’s not as potent of a weight reduction complement as substances like inexperienced tea extract or inexperienced espresso bean extract, the advantages are nonetheless welcome in case you are chubby and are taking berberine for metabolic well being. Simply don’t depend on it to do all the proverbial heavy lifting for you in the case of shedding pounds.

Q: How lengthy does it take for berberine to decrease blood sugar?

A: Most research on berberine for reducing blood sugar have examined their outcomes at six or eight weeks.

That’s to not say that important variations wouldn’t have emerged if these research have been concluded both, but it surely does counsel that you could be wish to be affected person when ready for outcomes from berberine. It’s not essentially going to be a fast in a single day repair, even when it does work.

Associated articles


Berberine has been studied as a pure complement for controlling blood sugar in folks with metabolic syndrome and kind two diabetes.

Furthermore, it has functions in controlling a few of the different adverse results of weight problems, resembling excessive blood ldl cholesterol and excessive blood lipids. Whereas berberine reveals some promise as a weight reduction product as effectively, its true power is in controlling the metabolic atmosphere in your physique, particularly when it’s confused by an unhealthy weight loss plan or carrying round further weight.

Some rising proof even means that berberine could possibly be useful for irritable bowel syndrome, however the causal pathways behind this will not be but clear.

Berberine is pretty secure, with gentle gastrointestinal uncomfortable side effects like constipation and abdomen ache sometimes reported. Berberine seems to be best when taken at dosage ranges of 900 to 1500 mg per day, break up into two to a few equal doses.

Berberine’s potential for controlling blood sugar, blood lipids, and different indicators of your physique’s metabolic well being is kind of robust, making it one of the thrilling natural dietary supplements in the marketplace proper now.

For BodyNutrition‘s #1 berberine advice, click on right here.

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