As an Amazon Associate I earn from qualifying purchases from

Rating one of the best PQQ dietary supplements of 2022

PQQ, quick for pyrroloquinoline quinone, is a biologically-active compound that may be taken as a complement to battle oxidative injury, increase your cognitive efficiency and shield your mind from free radicals, shield the operate of your mitochondria, and shield you from power illness.

These very broad advantages are the results of PQQ’s involvement in lots of the important organic reactions in your physique.

If you’d like a flexible complement that may increase your bodily power ranges, enhance your cognitive operate, and enhance your long-term well being, PQQ is an effective way to go.

Our researchers have regarded on the ten finest PQQ dietary supplements and ranked them in line with high quality.


1. Physician’s Finest PQQ

Verify worth at Amazon

Physician’s Finest has one of many cleanest PQQ dietary supplements on the market. Every vegetable cellulose capsule delivers 20 mg of the proprietary “BioPQQ” disodium salt type of PQQ, and except for the cellulose that makes up the capsule, there are zero extra elements. 

This making Physician’s Finest PQQ a wonderful selection for anybody who prioritizes easy and minimal complement design. By way of design, it doesn’t get any cleaner than this.

2. Well being Through Diet Naturally PQQ


Verify worth at Amazon

Well being Through Diet has a PQQ complement that delivers 20 mg of pure PQQ per vegetarian capsule, alongside a small quantity of calcium and a minimal quantity of different fillers and binders.

It’s a well-liked and dependable PQQ complement, making it well-suited for anybody in search of a pure and easy product.

3. Life Extension PQQ Caps

life extension pqq

Verify worth at Amazon

Life Extension is understood for his or her top quality and simple merchandise for longevity and wholesome getting old, and that repute actually applies to their PQQ complement.

With 20 mg of PQQ in a disodium salt type and no different energetic elements, you don’t have to fret about the rest interfering with the organic exercise of the PQQ. The complement design is fairly clear, too, with out a lot in the way in which of components or binders. It’s an all-around nice selection for PQQ.

4. Jarrow Formulation PQQ

71PaMmeF7JL. SY679

Verify worth at Amazon

Jarrow Formulation has a fairly normal PQQ complement; its solely distinguishing issue is that its capsule is constituted of gelatin as a substitute of the extra vegetarian-friendly cellulose in a few of its rivals.

This gained’t be a deal-breaker for most individuals, and it’s nonetheless a top quality product with 20 mg of PQQ per capsule.

5. Factor Nutraceuticals PQQ

61EUEY17L4L. SY679

Verify worth at Amazon

Factor Nutraceuticals makes a PQQ complement that’s among the many simplest, and is maybe the simplest PQQ complement available on the market that delivers PQQ in its pure type versus the disodium salt type of the complement.

The capsules are manufactured from gelatin, and except for that, the one different ingredient is rice flour. If you’d like pure PQQ, not the disodium salt type, this ought to be your selection.

6. Pure Encapsulations SR-CoQ10 with PQQ

61FEWsRMweL. SY679

Verify worth at Amazon

Pure Encapsulations makes an attention-grabbing PQQ complement that mixes the mitochondrial power selling results of PQQ with the antioxidant energy of CoQ10.

In case you are inquisitive about each of those dietary supplements for his or her potential longevity-promoting results, this may be a good selection, as you get 20 mg of PQQ and 100 mg of CoQ10 per capsule, and except for these two energetic elements, you don’t get a lot in the way in which of components, which is usually an issue with mixed dietary supplements.

7. Mitogenesis Tremendous PQQ Liquid

71J2Dap jL. SY679

Verify worth at Amazon

MItogenesis has an attention-grabbing tackle PQQ: as a substitute of delivering it in a capsule like virtually all different PQQ dietary supplements, this product delivers it in liquid type.

The PQQ is dissolved in a flavored water blended with monk fruit extract and pure mango flavoring. For a liquid complement, the ingredient composition is definitely fairly good: there’s nothing in the way in which of synthetic elements or components.

There’s 20 mg of PQQ per fluid ounce of answer, which makes measuring a little bit simpler, however this complement nonetheless suffers from the dosing difficulty: with out precision measuring instruments, it’s exhausting to make sure a exact dose.

8. Dr. Mercola Berberine and MicroPQQ

41LIXgr kCL

Verify worth at Amazon

There are just a few dietary supplements available on the market that mix PQQ with different biologically energetic compounds, together with Dr. Mercola Berberine and MicroPQQ.

Some make sense, however berberine (an natural extract from a European plant) is a much less logical mixture in relation to PQQ. There are many advantages to berberine, however most of them don’t fairly line up with the advantages of PQQ, so it doesn’t make a complete lot of sense to ship them on the identical time, until you might be particularly in search of each of those disparate elements in a single complement.

Even so, there are higher choices for every individually, and the PQQ content material (10 mg) is decrease than many different rivals.

9. Dr.’s Hope PQQ + CoQ10

61IKxZAm9wL. SY679

Verify worth at Amazon

Combining the mitochondrial boosting results of PQQ with the antioxidant energy of CoQ10 is standard, and Dr.’s Hope is one model that tries to capitalize on this combo.

The dosages of the energetic elements are stable (100 mg of CoQ10 and 20 mg of PQQ) however the complement design isn’t the cleanest.

There’s just a few too many components, particularly contemplating the truth that different corporations make related dietary supplements with much less in the way in which of binders and fillers.

10. Designs for Well being Mito-PQQ

61HlkWe UaL. SY679

Verify worth at Amazon

Designs for Well being is one other PQQ combo complement; this one combines PQQ with rhodiola rosea, an natural extract recognized largely for its capability to spice up cognitive operate, enhance libido, and burn fats.

Whereas these are all loads worthwhile goals, they don’t fairly line up with the makes use of of PQQ, which makes this considerably of an odd pairing.

Class winners

Finest PQQ total: Physician’s Finest PQQ

Physician’s Finest PQQ is a well-designed, minimalist PQQ complement with an efficient dosage and no extraneous elements. That’s precisely what you’re in search of when taking a focused compound like PQQ, which is why this complement takes the highest spot. 

Finest PQQ for cognitive operate: Life Extension PQQ Caps

Whether or not you’re aiming for a short-term nootropic impact or long-term safety of cognitive operate, Life Extension PQQ Caps are an important possibility. The 20 mg dosage is stable, and there aren’t any secondary elements that may have negative effects in your cognitive operate and efficiency. 

Finest PQQ for power ranges: Pure Encapsulations SR-CoQ10 with PQQ

Want a PQQ complement for emotions of sluggishness, tiredness, or lethargy? Pure Encapsulations SR-CoQ10 with PQQ is our advice attributable to its mixture of a particular type of CoQ10 with PQQ. This combo is designed to supply an additional increase to mitochondrial operate and increase your total power ranges. 

Finest PQQ for immune operate: Physician’s Finest PQQ

Boosting immune operate and combating off respiratory infections is among the major causes individuals take PQQ, and for this function we suggest Physician’s Finest PQQ. The 20 mg dosage and vegan-friendly cellulose capsules make this PQQ complement appropriate for anybody in search of an immunity increase. 

Finest PQQ for combating irritation: Physician’s Finest PQQ

For leveraging the antioxidant and anti inflammatory results of PQQ, our prime choose actually shines: its easy formulation means the PQQ could be quickly absorbed by your physique and the 20 mg dosage is precisely what you’d need when taking PQQ for irritation.

Finest PQQ for longevity: Life Extension PQQ Caps

PQQ’s highly effective antioxidant and anti inflammatory results make it a well-liked element of anti-aging and longevity supplementation stacks. For this use case we suggest Life Extension PQQ Caps due to its excessive dosage and pure formulation, which ensures it performs nicely with different dietary supplements in your routine. 

Who can purchase PQQ?

PQQ is mostly thought of protected for most individuals and will help shield your physique from oxidative injury, enhance your mind, and stop coronary heart injury. It may well additionally assist enhance mind well being and power in sure people.

Whereas interactions are restricted, it’s finest to talk to your physician earlier than starting a complement routine with PQQ, simply to be protected. Particular populations similar to diabetics, youngsters, and pregnant girls ought to keep away from PQQ till extra conclusive analysis comes out surrounding the efficacy and security of PQQ supplementation in these populations.

How we ranked

When rating one of the best PQQ dietary supplements available on the market, we first checked out dosages. In keeping with analysis, as much as 60mg of PQQ could be consumed per day. Nonetheless, we most popular a decrease dose of 20mg that may be break up up over the day and tailor-made to a person. That is why merchandise like Jarrow Formulation’s and Life Extension ranked so nicely on our record.

Subsequent, we checked out fillers and elements. Purity was king for us, which is why you gained’t discover any complement blends on our record. We additionally most popular merchandise that offered third-party lab testing outcomes, like Physician’s Finest, and included no synthetic elements, fillers, or components. Whereas many corporations regarded to incorporate CoQ10, we did favor corporations that included pure PQQ for our rankings, with out every other elements – even when they’re useful.

The type of PQQ was additionally essential to think about. Whereas normal PQQ wasn’t frowned upon, corporations that used the extra superior type referred to as BioPQQ have been rewarded, which is why Physician’s Finest took the highest spot on our record.


PQQ promotes progress and connective tissue operate. The significance of PQQ wasn’t realized till pretty not too long ago.

PQQ is current in hint quantities in lots of meals, so detecting the consequences of a PQQ poor weight loss plan was difficult. A 1989 research by researchers on the College of California Davis examined this intimately by feeding lab mice a weight loss plan that was particularly designed to be devoid of PQQ (1).

The research appeared within the prestigious journal Science, in contrast the expansion and growth of mice fed a regular weight loss plan to mice fed the specifically designed PQQ-deficient weight loss plan.

PQQ deficiency resulted in markedly decreased progress and substantial injury to connective tissue like pores and skin, tendons, and ligaments. This prompted the researchers to conclude that PQQ features like a progress issue, enabling tissue restore and progress.

This impact seems notably essential for collagen-containing tissue, like tendons, cartilage, and pores and skin. Along with extra conventional collagen-targeting compounds like glucosamine or different joint dietary supplements, PQQ could be useful for enhancing the standard of your connective tissue.

PQQ protects your physique from oxidative injury. The invention of the dietary significance of PQQ sparked a flurry of scientific analysis into its organic features.

A evaluation printed in 2016 within the scientific journal Bioscience, Biotechnology, and Biochemistry summarized a few of these features, highlighting the flexibility of PQQ to battle oxidative injury in your physique (2).

Oxidative injury is a chemical course of that’s been linked to getting old, power illnesses, and most cancers, amongst different ailing well being results. The dietary advantages of extra conventional and widely-recognized vitamins like vitamin C and vitamin E are considered, largely, attributable to their capability to stop or scale back oxidative injury.

So, what’s the proof for PQQ particularly? PQQ appears to guard vitally essential organic buildings like mitochondria and neural tissue from injury by free radicals, in line with one research printed within the journal Biochemical and Biophysical Analysis Communications (3).

This research discovered that PQQ exerted a robust protecting impact on mitochondria from rat coronary heart tissue, indicating that PQQ will help protect coronary heart well being. Different analysis has discovered that the antioxidant results of PQQ are even stronger than these of vitamin C or vitamin E (4).

PQQ helps protect and enhance mind operate. One of many varieties of cells that PQQ appears notably adept at defending from oxidative injury is neural tissue, which is present in copious portions in your mind.

Naturally, this led scientists to wonder if PQQ could possibly be used to assist heal injury to the mind and even enhance mind operate past its regular stage.

A number of the preliminary analysis into PQQ and cognitive operate used rat fashions to check the consequences of PQQ on oxidation-induced injury to the mind. A research printed in 2008 by researchers in Japan used extreme atmospheric oxygen ranges to induce oxidative injury to rats, then studied how their cognitive efficiency modified utilizing a maze navigation take a look at (5).

Of their experiment, some rats got a PQQ complement as part of their regular weight loss plan, whereas different rats served as controls, and weren’t given PQQ. The researchers discovered that the rats given PQQ didn’t endure as a lot mind injury, and realized to navigate the maze higher than mice not given the PQQ complement.

PQQ improves mitochondrial operate and might shield your coronary heart. Mitochondria are buildings inside cells in your physique that produce power.

They’re notably essential for muscular operate, and this extends past your skeletal muscle mass—your coronary heart is a muscle too, and it depends on mitochondrial operate. Analysis printed in 2007 by a group of scientists on the College of California San Francisco demonstrated that PQQ exerts protecting results on the mitochondria present in coronary heart cells utilizing a rat mannequin (6).

Within the presence of low concentrations of PQQ, cardiac cells are protected towards the consequences of oxidative injury. This implies that PQQ may function a protecting agent towards injury to your coronary heart, and will even have the ability to scale back the danger or reverse among the results of heart problems, although extra scientific analysis is required to supply proof for this.

Unwanted side effects

Resulting from its comparatively current discovery, there haven’t been any rigorous investigations into the unintended effects of PQQ within the type of a scientific trial.

Nonetheless, in line with analysis printed in 2015 by scientists at Osaka Prefecture College in Japan, a lot of animal research and a small variety of human trials haven’t discovered any poisonous results, despite the fact that the animal research used very excessive doses (7).

Moreover, PQQ has been on the business complement market since 2009 and the FDA has famous no adverse unintended effects associated to PQQ. So far, the security profile of PQQ appears robust.

Really helpful dose

To this point, human research are few and much between. The one human research to this point have used dosages starting from 20 to 60 mg per day.

Provided that the standard PQQ complement is available in a 20 mg dosage, this may translate into one to a few capsules per day, which should be equally spaced all through the day in case you are taking a couple of capsule.

As with different dietary supplements which can be on the chopping fringe of analysis, it makes probably the most sense to begin with a low dosage of PQQ and enhance it steadily for those who aren’t seeing the advantages you’d like.


Is PQQ essential within the physique? PQQ, which you might also see known as pyrroloquinoline quinone, can be utilized to battle oxidative injury, enhance your physique’s power manufacturing capability, and shield and even enhance your cognitive operate.

Although it’d look like a reasonably obscure biologically energetic chemical, it performs a important function within the regulation of among the most elementary features of your physique. There may be even some dialogue about whether or not it ought to be categorized as a vitamin, as a result of it’s not synthesized in your physique naturally—you must get it from both meals or a complement.

What’s PQQ? Pyrroloquinoline quinone (PQQ) is a compound that displays the exercise of Vitamin B and antioxidants. Regardless that it’s thought of an important vitamin, the human physique can’t create or synthesize PQQ by itself. As a part of the Vitamin B household, the physique wants PQQ to assist assist varied important bodily techniques and features associated to immune, neurological, and cardiovascular well being. 

With out ample PQQ, important bodily techniques could not operate effectively and will degenerate to an unhealthy diploma. Though people can’t make this important nutrient themselves, it’s attainable to acquire the required every day quantities from different sources, similar to your weight loss plan and dietary supplements. 

Is PQQ present in nature, or is it lab-grown? PQQ is present in nature, and can also be grown synthetically. It’s doubtless you already eat small quantities of PQQ every day, as it’s present in vegetation and lots of widespread meals. Whereas you will discover some stage of PQQ in most meals, some are notably wealthy with the nutrient. Meals similar to parsley, kiwis, inexperienced peppers, bananas, papaya, fava beans, and soy include greater ranges of PPQ than different fruits, greens, and legumes.  

Whereas it’s attainable to get sufficient PQQ by way of weight loss plan alone, it isn’t at all times handy and could also be costly. Most dietary supplements present between 20 mg-40 mg of PQQ per tablet, whereas the typical meals many individuals eat every day could present simply between 0.19−7.02 ng (ng stands for a nanogram, and a nanogram is one billionth of a gram (8)).

Instead, you should purchase artificial PQQ, which can be extra handy to take and prices lower than shopping for meals which can be wealthy within the nutrient.

Why do I want PQQ in my weight loss plan? PQQ helps many important features within the human physique. As you can not make this important vitamin naturally, it’s essential to incorporate it in your weight loss plan. Research have proven that animals who’ve a weight loss plan poor in PQQ have limitations on progress and copy (9). 

PQQ contributes to mitochondrial regeneration and progress, and mitochondria, that are the powerhouses of our cells, assist the physique to operate optimally. PQQ will help the nervous system, by boosting ranges of mitochondria, and have a useful impact on neurological well being in areas similar to reminiscence. As mitochondria are current in almost each cell within the human physique, PQQ could assist assist virtually each important bodily operate. 

Can PQQ assist to decrease stress ranges? A research involving 17 female and male contributors helps the suggestion that PQQ will help to scale back stress ranges. Every topic acquired 20 mg of PQQ every day for eight weeks. On the finish of the research, researchers discovered that the topic’s stress ranges have been decrease than earlier than that they had acquired the PQQ (10). 

Moreover, the researchers measured the quantity of cortisol secretion within the contributors. When feeling stress or stress, people have a tendency to provide greater quantities of cortisol. In keeping with the above research, cortisol secretions diminished following the administration of PQQ.

Can PQQ assist me as a part of an train routine? PQQ will help as a part of a wholesome life-style by aiding the physique to get better after train. One of many outcomes of strenuous bodily exercise is that muscle fibers break down, and so they can develop into infected. There may be research-based proof that demonstrates PQQ will help to scale back irritation by decreasing the quantities of particular proteins and amines (11). 

This conclusion is probably going because of the highly effective antioxidant results of PQQ, considered between 30-100 instances extra environment friendly than Vitamin C. As Vitamin C is a potent antioxidant, this could possibly be a big discovering for each skilled and leisure athletes.

Can PQQ provide safety towards sickness? The human physique requires nutritional vitamins and vitamins to assist it battle off sickness and illness. There may be proof that PQQ could scale back the signs of Alzheimer’s illness by regenerating cells, and in addition by suppressing the consequences of proteins that specialists consider contribute to cell demise (12). Moreover, analysis suggests PQQ may have a job to play in remedy following a stroke. 

Physicians measure infarct dimension following a affected person having a stroke, and this research reveals that the scale diminished following the administration of PQQ (13). Infarct dimension refers back to the space of necrotic, or useless tissue within the mind after a stroke. 

Relying on the realm and dimension of the infarct, sufferers could show totally different signs and have various therapeutic outcomes. Specialists consider the smaller the realm of useless tissue, the higher when it comes to likelihood of restoration. They assume PQQ could act as a neuroprotective for mind tissue, which may play a big function in medical therapy following a stroke.

Can PQQ assist with pores and skin situations? PQQ could assist to encourage wholesome and supple pores and skin. Scientists have discovered {that a} weight loss plan that doesn’t include PQQ could cause the pores and skin to develop into fragile (14). 

As researchers have additionally demonstrated that one of many major results of PQQ is to stimulate mitochondria era, this additionally suggests there are advantages for skincare (15).

If mitochondria don’t present power to cells, they will develop into weaker and will die. By encouraging the expansion of mitochondria, PQQ could assist to supply essential vitality to pores and skin cells, sustaining their energy and enhancing your capability to battle situations similar to dry or flaky pores and skin.

Does PQQ encourage higher sleep? There are a number of methods to assist enhance sleep, and PQQ would possibly play an important function. Your bodily techniques want assist to operate accurately. If this assist is lacking, your features can deteriorate, and your physique could lose its pure balances and rhythms. 

By serving to pores and skin to remain wholesome, contributing to resisting diseases, encouraging muscle restoration after bodily train, and decreasing cortisol launched throughout anxious conditions, PQQ will help your physique to keep up its equilibrium. 

Stress, sickness, and different adverse elements could cause a disturbance in your sleep patterns. PQQ could assist scale back the consequences of many uncomfortable situations and contribute to a greater night time’s sleep.

Can PQQ give me extra power? Analysis means that PQQ will help to assist power ranges and {that a} weight loss plan that’s poor in PQQ may trigger a lower in vitality (16).

The optimistic results on mitochondria assist the suggestion that cell progress and proliferation profit from PQQ. Nonetheless, there could also be different advantages that come from the contribution of PQQ to a number of important bodily processes. 

If in case you have a depressing night time’s sleep, you are inclined to really feel sluggish the following day. Equally, in case you are sick, your physique makes use of power to battle the sickness, which may subsequently make you are feeling much less energetic. By supporting these processes, PQQ can provide a complete strategy to wellness that encourages pure homeostasis and will increase power ranges all through the day.

Ought to I embrace PQQ in a heart-healthy weight loss plan? In the event you’re already residing a wholesome life-style and embracing a weight loss plan that’s wholesome to your cardiovascular system, you possibly can nonetheless profit from the consequences of PQQ. Science has already confirmed that train and fruit and greens contribute to a virile system, however analysis now means that PQQ could assist to boost these results (17). 

Oxidative stress causes cell demise, which may injury your cardiovascular system. Whereas PPQ alone can’t stop this from occurring, it’s value together with PQQ into your complete nutritious diet and train plan.

Can I take PQQ if I’ve excessive ldl cholesterol? Sure, taking a PQQ complement could allow you to to scale back your levels of cholesterol. It’s well-known that having excessive ldl cholesterol can enhance your threat of sure situations similar to coronary heart illness, stroke, and cardiac arrest. Decreasing levels of cholesterol normally requires pharmaceutical medicine generally known as statins. 

When you ought to by no means cease taking prescribed medicine with out first consulting your doctor, you possibly can embrace PQQ as a part of a balanced weight loss plan. Researchers carried out a research by administering 20mg PQQ every day for 12 weeks to 29 wholesome Japanese adults who had barely irregular levels of cholesterol (18). 

The scientists discovered on the trial’s conclusion that there was a big lower within the LDL ranges of ldl cholesterol. Specialists hyperlink LDL to a number of extreme life-style situations, similar to atherosclerosis. This situation happens when fats builds up within the arteries, inflicting them to slender. If left untreated, this will enhance the danger of peripheral artery illness, coronary heart assault, and stroke. Utilizing PQQ could assist decrease your LDL ranges, decreasing your threat of great sickness or power illness.

What dosage of PQQ ought to I take? PPQ could have advantages at as little as 2 mg. Nonetheless, it is a low dose, and dietary supplements commonly present doses between 20 and 40 mg.

To acquire probably the most advantageous advantages, maintain cell power, and encourage cell regeneration and progress, your physique could profit from the upper doses contained in PQQ dietary supplements – which is why all of the merchandise in our rankings present at the least 20mg per serving..  

Do I want to make use of different dietary supplements together with PQQ? No proof suggests taking different dietary supplements can improve the consequences of PQQ. Analysis means that PQQ can resist the consequences of cognitive decline and that this response can happen even when you don’t use different dietary supplements while you’re utilizing PQQ (19). 

You may embrace PQQ as a part of a wholesome life-style, and it could assist enhance many elements of your well being, together with mind operate, cardiovascular well being, and your immune system. Nonetheless, though you possibly can mix it with different dietary supplements, this isn’t essential.

Why is it essential that I take PQQ dietary supplements? PQQ doesn’t simply profit one space of the physique; it could actually have an effect on many alternative techniques by way of its motion on mitochondria. As you possibly can’t synthesize it naturally, a complement is a handy, straightforward, and inexpensive approach to get hold of your really helpful every day dose.

Associated articles


PQQ is a brand new and thrilling complement that is a crucial antioxidant, progress issue, and protecting agent for neural and cardiac tissue.

It could possibly be helpful for stopping or reversing injury to cognitive operate, coronary heart operate, and the structural integrity of connective tissue like pores and skin, tendons, and collagen.

Whereas analysis into PQQ is within the early phases, it seems to have a great security profile, and early indicators are pointing in the direction of doses within the vary of 20 to 60 mg per day.

Given the wide selection of potential makes use of for this complement, PQQ has a brilliant future.

For BodyNutrition’s #1 really helpful PQQ complement, click on right here.

We will be happy to hear your thoughts

Leave a reply

Enable registration in settings - general
Compare items
  • Total (0)
Shopping cart